Retrotransposons and aging - Publication List

  1. Van Meter M, Simon M, Tombline G, May A, Morello TD, Hubbard BP, Bredbenner K, Park R, Sinclair DA, Bohr VA, Gorbunova V, Seluanov A (2016). JNK phosphorylates SIRT6 to stimulate DNA doublestrand break repair in response to oxidative stress by recruiting PARP1 to DNA breaks. Cell Rep 16: 2641-2650. Epub: 2016/08/30; PMID: 27568560; PMC5089070; doi: 10.1016/j.celrep.2016.08.006.

  2. Wood JG, Jones BC, Jiang N, Chang C, Hosier S, Wickremesinghe P, Garcia M, Hartnett DA, Burhenn L, Neretti N, Helfand SL (2016). Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila. Proc Natl Acad Sci USA 113: 11277-11282. Epub: 2016/09/14; PMID: 27621458; PMC5056045; doi: 10.1073/pnas.1604621113.

  3. Bacalini MG, Deelen J, Pirazzini C, De Cecco M, Giuliani C, Lanzarini C, Ravaioli F, Marasco E, van Heemst D, Suchiman HED, Slieker R, Giampieri E, Recchioni R, Marcheselli F, Salvioli S, Vitale G, Olivieri F, Spijkerman AMW, Dolle MET, Sedivy JM, Castellani G, Franceschi C, Slagboom PE, Garagnani P (2017). Systemic age-associated DNA hypermethylation of ELOVL2 gene: In vivo and in vitro evidences of a cell replication process. J Gerontol A Biol Sci Med Sci 72: 1015-1023. Epub:2016/09/28; PMID: 27672102; PMC5861890; doi: 10.1093/gerona/glw185.

  4. Mita P, Savas JN, Briggs EM, Ha S, Gnanakkan V, Yates JR, 3rd, Robins DM, David G, Boeke JD, Garabedian MJ, Logan SK (2016). URI Regulates KAP1 Phosphorylation and Transcriptional Repression via PP2A Phosphatase in Prostate Cancer Cells. J Biol Chem 291: 25516-25528. Epub: 2016/10/27; PMID: 27780869; PMC5207251; doi: 10.1074/jbc.M116.741660.

  5. Zampella JG, Rodic N, Yang WR, Huang CR, Welch J, Gnanakkan VP, Cornish TC, Boeke JD, Burns KH (2016). A map of mobile DNA insertions in the NCI-60 human cancer cell panel. Mob DNA 7: 20. Epub: 2016/11/04; PMID: 27807467; PMC5087121; doi: 10.1186/s13100-016-0078-4.

  6. Achanta P, Steranka JP, Tang Z, Rodic N, Sharma R, Yang WR, Ma S, Grivainis M, Huang CRL, Schneider AM, Gallia GL, Riggins GJ, Quinones-Hinojosa A, Fenyo D, Boeke JD, Burns KH (2016). Somatic retrotransposition is infrequent in glioblastomas. Mob DNA 7: 22. Epub: 2016/11/16; PMID: 27843500; PMC5105304; doi: 10.1186/s13100-016-0077-5.

  7. Jones BC, Wood JG, Chang C, Tam AD, Franklin MJ, Siegel ER, Helfand SL (2016). A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan. Nat Commun 7: 13856. Epub: 2016/12/22; PMID: 28000665; PMC5187580; doi: 10.1038/ncomms13856.

  8. Tang Z, Steranka JP, Ma S, Grivainis M, Rodic N, Huang CR, Shih IM, Wang TL, Boeke JD, Fenyo D, Burns KH (2017). Human transposon insertion profiling: Analysis, visualization and identification of somatic LINE-1 insertions in ovarian cancer. Proc Natl Acad Sci U S A 114: E733-E740. Epub: 2017/01/18; PMID: 28096347; PMC5293032; doi: 10.1073/pnas.1619797114.

  9. Payer LM, Steranka JP, Yang WR, Kryatova M, Medabalimi S, Ardeljan D, Liu C, Boeke JD, Avramopoulos D, Burns KH (2017). Structural variants caused by Alu insertions are associated with risks for many human diseases. Proc Natl Acad Sci U S A 114: E3984-E3992. Epub: 2017/05/04; PMID: 28465436; PMC5441760; doi: 10.1073/pnas.1704117114.

  10. Kannan M, Li J, Fritz SE, Husarek KE, Sanford JC, Sullivan TL, Tiwary PK, An W, Boeke JD, Symer DE (2017). Dynamic silencing of somatic L1 retrotransposon insertions reflects the developmental and cellular contexts of their genomic integration. Mob DNA 8: 8. Epub: 2017/05/12; PMID: 28491150; PMC5424313; doi: 10.1186/s13100-017-0091-2.

  11. Kreiling JA, Jones BC, Wood JG, De Cecco M, Criscione SW, Neretti N, Helfand SL, Sedivy JM. Contribution of retrotransposable elements to aging. In: Cristofari G, editor. Human Retrotransposons in Health and Disease: Springer; 2017.

  12. Newkirk SJ, Lee S, Grandi FC, Gaysinskaya V, Rosser JM, Vanden Berg N, Hogarth CA, Marchetto MCN, Muotri AR, Griswold MD, Ye P, Bortvin A, Gage FH, Boeke JD, An W (2017). Intact piRNA pathway prevents L1 mobilization in male meiosis. Proc Natl Acad Sci U S A 114: E5635-E5644. Epub: 2017/06/21; PMID: 28630288; PMC5514719; doi: 10.1073/pnas.1701069114.

  13. Tan L, Ke Z, Tombline G, Macoretta N, Hayes K, Tian X, Lv R, Ablaeva J, Gilbert M, Bhanu NV, Yuan ZF, Garcia BA, Shi YG, Shi Y, Seluanov A, Gorbunova V (2017). Naked mole rat cells have a stableepigenome that resists iPSC reprogramming. Stem Cell Reports 9: 1721-1734. Epub: 2017/11/07; PMID: 29107597; PMC5831052; doi: 10.1016/j.stemcr.2017.10.001.

  14. Mita P, Wudzinska A, Sun X, Andrade J, Nayak S, Kahler DJ, Badri S, LaCava J, Ueberheide B, Yun CY,

  15. Fenyo D, Boeke JD (2018). LINE-1 protein localization and functional dynamics during the cell cycle. Elife 7. Epub: 2018/01/09; PMID: 29309036; PMC5821460; doi: 10.7554/eLife.30058.

  16. Taylor MS, Altukhov I, Molloy KR, Mita P, Jiang H, Adney EM, Wudzinska A, Badri S, Ischenko D, Eng G, Burns KH, Fenyo D, Chait BT, Alexeev D, Rout MP, Boeke JD, LaCava J (2018). Dissection of affinity captured LINE-1 macromolecular complexes. Elife 7. Epub: 2018/01/09; PMID: 29309035; PMC5821459; doi: 10.7554/eLife.30094.

  17. Wood JG, Schwer B, Wickremesinghe PC, Hartnett DA, Burhenn L, Garcia M, Li M, Verdin E, Helfand SL (2018). Sirt4 is a mitochondrial regulator of metabolism and lifespan in Drosophila melanogaster. Proc Natl Acad Sci U S A 115: 1564-1569. Epub: 2018/01/31; PMID: 29378963; PMC5816209; doi: 10.1073/pnas.1720673115.

  18. Waaijer MEC, Gunn DA, van Heemst D, Slagboom PE, Sedivy JM, Dirks RW, Tanke HJ, Westendorp RGJ, Maier AB (2018). Do senescence markers correlate in vitro and in situ within individual human donors? Aging (Albany NY) 10: 278-289. Epub: 2018/03/04; PMID: 29500330; PMC5842854; doi: 10.18632/aging.101389.

  19. Ito T, Teo YV, Evans SA, Neretti N, Sedivy JM (2018). Regulation of cellular cenescence by Polycomb chromatin modifiers through distinct DNA damage- and histone methylation-dependent pathways. CellRep 22: 3480-3492. Epub: 2018/03/29; PMID: 29590617; PMC5915310; doi: 10.1016/j.celrep.2018.03.002.

  20. Sun X, Wang X, Tang Z, Grivainis M, Kahler D, Yun C, Mita P, Fenyo D, Boeke JD (2018). Transcription factor profiling reveals molecular choreography and key regulators of human retrotransposon expression. Proc Natl Acad Sci U S A 115: E5526-E5535. Epub: 2018/05/29; PMID: 29802231; PMC6004460; doi: 10.1073/pnas.1722565115.

  21. Mita P, Boeke JD (2018). Cycling to maintain and improve fitness: Line-1 modes of nuclear entrance and retrotransposition. SLAS Discov 23: 491-494. Epub: 2018/05/05; PMID: 29724131; doi: 10.1177/2472555218767842.

  22. Abrams JM, Arkhipova IR, Belfort M, Boeke JD, Joan Curcio M, Faulkner GJ, Goodier JL, Lehmann R, Levin HL (2018). Meeting report: mobile genetic elements and genome plasticity 2018. Mob DNA 9: 21. Epub: 2018/09/14; PMID: 30211913; PMC6015446; doi: 10.1186/s13100-018-0126-3.

  23. Bourque G, Burns KH, Gehring M, Gorbunova V, Seluanov A, Hammell M, Imbeault M, Izsvak Z, Levin HL, Macfarlan TS, Mager DL, Feschotte C (2018). Ten things you should know about transposable elements. Genome Biol 19: 199. Epub: 2018/11/21; PMID: 30454069; PMC6240941; doi: 10.1186/s13059-018-1577-z.

  24. De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beausejour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM (2019). L1 drives IFN in senescent cells and promotes age-associated inflammation. Nature 566: 73-78. Epub: 2019/02/08; PMID: 30728521; PMC6519963; doi: 10.1038/s41586-018-0784-9.

  25. Steranka JP, Tang Z, Grivainis M, Huang CRL, Payer LM, Rego FOR, Miller TLA, Galante PAF, Ramaswami S, Heguy A, Fenyo D, Boeke JD, Burns KH (2019). Transposon insertion profiling by sequencing (TIPseq) for mapping LINE-1 insertions in the human genome. Mob DNA 10: 8. Epub: 2019/03/23; PMID: 30899333; PMC6407172; doi: 10.1186/s13100-019-0148-5.

  26. Simon M, Van Meter M, Ablaeva J, Ke Z, Gonzalez RS, Taguchi T, De Cecco M, Leonova KI, Kogan V, Helfand SL, Neretti N, Roichman A, Cohen HY, Meer MV, Gladyshev VN, Antoch MP, Gudkov AV, Sedivy JM, Seluanov A, Gorbunova V (2019). LINE1 derepression in aged wild-type and SIRT6-deficient mice drives inflammation. Cell Metab 29: 871-885 e5. Epub: 2019/03/12; PMID: 30853213; PMC6449196; doi: 10.1016/j.cmet.2019.02.014.

  27. Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V (2019). SIRT6 is responsible for more efficient DNA double-strand break repair in long-lived species. Cell 177: 622-638 e22. Epub: 2019/04/20; PMID: 31002797; PMC6499390; doi: 10.1016/j.cell.2019.03.043.

  28. Hayano M, Yang J-H, Bonkowski MS, Amorim JA, Ross JM, Coppotelli G, Griffin PT, Chew YC, Guo W, Yang X, Vera DL, Salfati EL, Das A, Thakur S, Kane AE, Mitchell SJ, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta A-M, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Oberdoerffer P, Ksander BR, Rajman LA, Sinclair DA (2019). DNA break induced epigenetic drift as a cause of mammalian aging. bioRxiv: 808659. Epub; doi: 10.1101/808659.

  29. Rezazadeh S, Yang D, Tombline G, Simon M, Regan SP, Seluanov A, Gorbunova V (2019). SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170. Nucleic Acids Res 47: 7914-7928. Epub: 2019/06/20; PMID: 31216030; PMC6736037; doi: 10.1093/nar/gkz528.

  30. Katagi H, Louis N, Unruh D, Sasaki T, He X, Zhang A, Ma Q, Piunti A, Shimazu Y, Lamano JB, Carcaboso AM, Tian X, Seluanov A, Gorbunova V, Laurie KL, Kondo A, Wadhwani NR, Lulla R, Goldman S, Venneti S, Becher OJ, Zou L, Shilatifard A, Hashizume R (2019). Radiosensitization by Histone H3 Demethylase Inhibition in Diffuse Intrinsic Pontine Glioma. Clin Cancer Res 25: 5572-5583. Epub:2019/06/23; PMID: 31227500; PMC6744979; doi: 10.1158/1078-0432.CCR-18-3890.

  31. Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, Su T, Shi J, Jiang C, Tian X, Seluanov A, Huang J, Wan X, Jiang Y, Gorbunova V, Mao Z (2019). A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites. Nucleic Acids Res 47: 8563-8580. Epub: 2019/07/11; PMID: 31291457; PMC7145522; doi: 10.1093/nar/gkz592.

  32. Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer L, Passos JF, Robbins PD, Schmitt CA, Sedivy J, Vougas K, von Zglinicki T, Zhou D, Serrano M, Demaria M (2019). Cellular senescence: Defining a path forward. Cell 179: 813-827. Epub: 2019/11/02; PMID: 31675495; doi: 10.1016/j.cell.2019.10.005.

  33. Adney EM, Ochmann MT, Sil S, Truong DM, Mita P, Wang X, Kahler DJ, Fenyo D, Holt LJ, Boeke JD (2019). Comprehensive scanning mutagenesis of human retrotransposon LINE-1 identifies motifs essential for function. Genetics 213: 1401-1414. Epub: 2019/11/02; PMID: 31666291; PMC6893370; doi: 10.1534/genetics.119.302601.

  34. Tombline G, Gigas J, Macoretta N, Zacher M, Emmrich S, Zhao Y, Seluanov A, Gorbunova V (2020). Proteomics of Long-Lived Mammals. Proteomics 20: e1800416. Epub: 2019/11/19; PMID: 31737995; PMC7117992; doi: 10.1002/pmic.201800416.

  35. Ardeljan D, Steranka JP, Liu C, Li Z, Taylor MS, Payer LM, Gorbounov M, Sarnecki JS, Deshpande V, Hruban RH, Boeke JD, Fenyo D, Wu PH, Smogorzewska A, Holland AJ, Burns KH (2020). Cell fitness screens reveal a conflict between LINE-1 retrotransposition and DNA replication. Nat Struct Mol Biol 27: 168-178. Epub: 2020/02/12; PMID: 32042151; PMC7080318; doi: 10.1038/s41594-020-0372-1.

  36. Mita P, Sun X, Fenyo D, Kahler DJ, Li D, Agmon N, Wudzinska A, Keegan S, Bader JS, Yun C, Boeke JD (2020). BRCA1 and S phase DNA repair pathways restrict LINE-1 retrotransposition in human cells. Nat Struct Mol Biol 27: 179-191. Epub: 2020/02/12; PMID: 32042152; PMC7082080; doi:10.1038/s41594-020-0374-z.

  37. McKerrow W, Tang Z, Steranka JP, Payer LM, Boeke JD, Keefe D, Fenyo D, Burns KH, Liu C (2020). Human transposon insertion profiling by sequencing (TIPseq) to map LINE-1 insertions in single cells. Philos Trans R Soc Lond B Biol Sci 375: 20190335. Epub: 2020/02/23; PMID: 32075555; PMC7061987; doi: 10.1098/rstb.2019.0335.

  38. Kumar V, Agrawal R, Pandey A, Kopf S, Hoeffgen M, Kaymak S, Bandapalli OR, Gorbunova V, Seluanov A, Mall MA, Herzig S, Nawroth PP (2020). Compromised DNA repair is responsible for diabetes associated fibrosis. EMBO J 39: e103477. Epub: 2020/04/28; PMID: 32338774; PMC7265245; doi: 10.15252/embj.2019103477.

  39. Takasugi M, Firsanov D, Tombline G, Ning H, Ablaeva J, Seluanov A, Gorbunova V (2020). Naked mole rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties. Nat Commun 11: 2376. Epub: 2020/05/14; PMID: 32398747; PMC7217962; doi: 10.1038/s41467-020-16050-w.

  40. Rezazadeh S, Yang D, Biashad SA, Firsanov D, Takasugi M, Gilbert M, Tombline G, Bhanu NV, Garcia BA, Seluanov A, Gorbunova V (2020). SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair. Aging (Albany NY) 12: 11165-11184. Epub: 2020/06/26; PMID: 32584788; PMC7343504; doi: 10.18632/aging.103567.

  41. Gorbunova V, Seluanov A, Kennedy BK (2020). The World Goes Bats: Living Longer and Tolerating Viruses. Cell Metab 32: 31-43. Epub: 2020/07/09; PMID: 32640245; PMC7341951; doi: 10.1016/j.cmet.2020.06.013.

  42. Cohen AA, Kennedy BK, Anglas U, Bronikowski AM, Deelen J, Dufour F, Ferbeyre G, Ferrucci L, Franceschi C, Frasca D, Friguet B, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Gut P, Ivanchenko M, Legault V, Lemaitre JF, Liontis T, Liu GH, Liu M, Maier AB, Nobrega OT, Olde Rikkert MGM, Pawelec G, Rheault S, Senior AM, Simm A, Soo S, Traa A, Ukraintseva S, Vanhaelen Q, Van Raamsdonk JM, Witkowski JM, Yashin AI, Ziman R, Fulop T (2020). Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. Mech Ageing Dev 191: 111316. Epub: 2020/07/22; PMID: 32693105; PMC7603428; doi: 10.1016/j.mad.2020.111316.

  43. Zhang ZD, Milman S, Lin JR, Wierbowski S, Yu H, Barzilai N, Gorbunova V, Ladiges WC, Niedernhofer LJ, Suh Y, Robbins PD, Vijg J (2020). Genetics of extreme human longevity to guide drug discovery for healthy ageing. Nat Metab 2: 663-672. Epub: 2020/07/29; PMID: 32719537; doi: 10.1038/s42255-020- 0247-0.

  44. Zhou X, Dou Q, Fan G, Zhang Q, Sanderford M, Kaya A, Johnson J, Karlsson EK, Tian X, Mikhalchenko A, Kumar S, Seluanov A, Zhang ZD, Gorbunova V, Liu X, Gladyshev VN (2020). Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity. Cell Rep 32: 107949. Epub: 2020/07/30; PMID: 32726638; doi: 10.1016/j.celrep.2020.107949.

  45. Gorbunova V, Takasugi M, Seluanov A (2020). Hyaluronan goes to great length. Cell Stress 4: 227-229. Epub: 2020/09/11; PMID: 32908962; PMC7453635; doi: 10.15698/cst2020.09.231.

  46. Pawelec G, Bronikowski A, Cunnane SC, Ferrucci L, Franceschi C, Fulop T, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Kennedy BK, Larbi A, Lemaitre JF, Liu GH, Maier AB, Morais JA, Nobrega OT, Moskalev A, Rikkert MO, Seluanov A, Senior AM, Ukraintseva S, Vanhaelen Q, Witkowski J, Cohen AA (2020). The conundrum of human immune system "senescence". Mech Ageing Dev 192: 111357. Epub: 2020/09/20; PMID: 32949594; PMC7494491; doi: 10.1016/j.mad.2020.111357.

  47. Wang Y, Zheng JP, Luo Y, Wang J, Xu L, Wang J, Sedivy JM, Song Z, Wang H, Ju Z (2020). L1 drives HSC aging and affects prognosis of chronic myelomonocytic leukemia. Signal Transduct Target Ther 5: 205. Epub: 2020/09/21; PMID: 32951008; PMC7502075; doi: 10.1038/s41392-020-00279-4.

  48. Newton J, Li G, Naik M, Fawzi N, Sedivy J, Jogl G (2020). Phase separation of the LINE-1 ORF1 protein is mediated by the N-terminus and coiled-coil domain.  Biophys J. 2021 Jun 1;120(11):2181-2191. doi: 10.1016/j.bpj.2021.03.028. Epub 2021 Mar 31. PMID: 33798566; PMCID: PMC8390800.

  49. Chini CCS, Peclat TR, Warner GM, Kashyap S, Espindola-Netto JM, de Oliveira GC, Gomez LS, Hogan KA, Tarrago MG, Puranik AS, Agorrody G, Thompson KL, Dang K, Clarke S, Childs BG, Kanamori KS, Witte MA, Vidal P, Kirkland AL, De Cecco M, Chellappa K, McReynolds MR, Jankowski C, Tchkonia T, Kirkland JL, Sedivy JM, van Deursen JM, Baker DJ, van Schooten W, Rabinowitz JD, Baur JA, Chini EN (2020). CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD(+) and NMN levels. Nat Metab 2: 1284-1304. Epub: 2020/11/18; PMID: 33199925; doi: 10.1038/s42255-020-00298-z.

  50. Swovick K, Firsanov D, Welle KA, Hryhorenko J, Wise JP, George C, Sformo TL, Seluanov A, Gorbunova V, Ghaemmaghami S (2020). Interspecies differences in proteome turnover kinetics are correlated with lifespans and energetic demands. Mol Cell Proteomics. Epub: 2020/12/30; PMID: 33372049; doi: 10.1074/mcp.RA120.002301.

  51. Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-Garcia CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M (2020). ARDD 2020: from aging mechanisms to interventions. Aging (Albany NY) 24484-24503. Epub: 2020/12/31; PMID: 33378272; doi: 10.18632/aging.202454.

  52. Taguchi T, Kotelsky A, Takasugi M, Chang M, Ke Z, Betancourt M, Buckley MR, Zuscik M, Seluanov A, Gorbunova V. Naked mole-rats are extremely resistant to post-traumatic osteoarthritis. Aging cell. 2020 November;19(11):e13255. PubMed PMID: 33112509; PubMed Central PMCID: PMC7681040; DOI: 10.1111/acel.13255.

  53. Simon M, Yang J, Gigas J, Earley EJ, Hillpot E, Zhang L, Zagorulya M, Tombline G, Gilbert M, Yuen SL, Pope A, Van Meter M, Emmrich S, Firsanov D, Athreya A, Biashad SA, Han J, Ryu S, Tare A, Zhu Y, Hudgins A, Atzmon G, Barzilai N, Wolfe A, Moody K, Garcia BA, Thomas DD, Robbins PD, Vijg J, Seluanov A, Suh Y, Gorbunova V. A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A. The EMBO journal. 2022 November 2;41(21):e110393. PubMed PMID: 36215696; PubMed Central PMCID: PMC9627671; DOI: 10.15252/embj.2021110393.

  54. Herdy JR, Traxler L, Agarwal RK, Karbacher L, Schlachetzki JCM, Boehnke L, Zangwill D, Galasko D, Glass CK, Mertens J, Gage FH. Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease. Cell stem cell. 2022 December 1;29(12):1637-1652.e6. PubMed PMID: 36459967; PubMed Central PMCID: PMC10093780; DOI: 10.1016/j.stem.2022.11.010.

  55. Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O'Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA. Loss of epigenetic information as a cause of mammalian aging. Cell. 2023 January 19;186(2):305-326.e27. PubMed PMID: 36638792; PubMed Central PMCID: PMC10166133; DOI: 10.1016/j.cell.2022.12.027.

  56. Zhao Y, Simon M, Seluanov A, Gorbunova V. DNA damage and repair in age-related inflammation. Nature reviews. Immunology. 2023 February;23(2):75-89. PubMed PMID: 35831609; PubMed Central PMCID: PMC10106081; DOI: 10.1038/s41577-022-00751-y.

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